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SUMMARY:Biomolecular condensates at the nexus of cellular stress\, disease
  and aging - Simon  Alberti (Technische Universität Dresden)
DTSTART:20231009T150000Z
DTEND:20231009T160000Z
UID:TALK204766@talks.cam.ac.uk
DESCRIPTION:Stress-inducible biomolecular condensates such as ribonucleopr
 otein (RNP) granules and DNA damage sites play major roles in cellular org
 anization and physiology. In this talk\, I will discuss how the concept of
  biomolecular condensates has expanded our view of stress responses and ha
 s revealed important links to aging-related diseases. I will introduce qua
 ntitative bottom-up biochemistry approaches that now allow us to reconstru
 ct multicomponent\, active condensates such as RNP granules and DNA damage
  sites in the test tube. Using these approaches as well as innovative imag
 ing and biophysics\, we have gained important insights into the molecular 
 rules underlying condensate assembly\, such as the molecular driving force
 s that govern condensation\, the conformational changes underlying assembl
 y and the molecular mechanisms of condensate regulation. I will further di
 scuss how the concept of biomolecular condensates has allowed us to dissec
 t the functions of stress inducible condensates\, and I will demonstrate h
 ow condensates can be used to sense and respond to changes in the environm
 ent and regulate fundamental cellular processes such as protein synthesis 
 and DNA damage repair.
LOCATION:Seminar Room 1\, Newton Institute
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