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SUMMARY:Multiscale modelling of liquid-like chromatin organisation - Rosan
 a Collepardo Guevara (University of Cambridge)
DTSTART:20231010T103000Z
DTEND:20231010T112000Z
UID:TALK204787@talks.cam.ac.uk
DESCRIPTION:The three-dimensional organisation of the DNA is one of the gr
 eat marvels of physical biology. By winding around a special class of prot
 eins\, the metre-long DNA manages to compress enormously to fit inside tin
 y (6 &mu\;m) nuclei\, avoid entanglement and\, moreover\, maintain exquisi
 te control over the accessibility of the information it carries. The struc
 ture of this remarkable complex of DNA and proteins\, known as chromatin\,
  determines how easily the DNA can be accessed and\, thus\, it is intimate
 ly linked to gene expression regulation. In this talk\, I will present our
  multiscale modelling techniques designed to investigate the structure of 
 chromatin in conditions that mimic those inside cells (Farr et al\, Nature
  Communications\, 2021). I will discuss why nucleosomes\, the building blo
 cks of chromatin\, should be viewed as highly plastic particles that foste
 r multivalent interactions and promote chromatin&rsquo\;s liquid-liquid ph
 ase separation.
LOCATION:Seminar Room 1\, Newton Institute
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