BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Stabilization of biological emulsions by interfacial protein clust
 ers - Andrea Putnam (University of Wisconsin-Madison)
DTSTART:20231010T125000Z
DTEND:20231010T133000Z
UID:TALK204790@talks.cam.ac.uk
DESCRIPTION:Emulsions of condensed droplets (condensates) enriched in prot
 eins and RNA have been identified in virtually all biological processes an
 d include structures such as nucleoli\, stress granules\, and germ granule
 s. A critical feature of emulsions is that they are unstable and over time
  small droplets coalesce and grow to form larger droplets (coarsening) unt
 il an equilibrium is reached\, leading to only two distinct phases. Biolog
 ical systems have evolved unique solutions to counter coarsening\, and mos
 t cellular emulsions exhibit unexpected stability\, with small liquid drop
 lets persisting for extended periods. We show that P granules\, a dynamic 
 yet stable emulsion in germ cells of C. elegans\, are coated by nanoscale 
 solid clusters of the protein\, MEG-3\, which prevents droplet growth by r
 educing surface tension and inhibiting coalescence.&nbsp\; Here\, we will 
 discuss the potential of interfacial clusters in the stabilization and reg
 ulation of dynamic cellular emulsions.
LOCATION:Seminar Room 1\, Newton Institute
END:VEVENT
END:VCALENDAR