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SUMMARY:Conversion-limited phase separation in biomolecular condensation -
  Chiu Fan Lee (Imperial College London)
DTSTART:20231012T144000Z
DTEND:20231012T152000Z
UID:TALK204796@talks.cam.ac.uk
DESCRIPTION:Phase separation plays an important organisational role in cel
 ls. However\, experimental studies of intracellular biomolecular condensat
 es have challenged the standard kinetic theories of phase separation. Spec
 ifically\, the coarsening rates observed are unexpectedly slow for many in
 tracellular condensates. Partly motivated by the slow fibrillisation kinet
 ics in amyloid formation [1]\, a conversion-limited scheme of phase separa
 tion has recently been proposed to account for the in vivo observation of 
 the slow coarsening kinetics of P granules in C. elegans. [2\,3]. In conve
 rsion-limited phase separation\, the bottleneck of the coarsening rate is 
 the slow conversion of a condensate constituent between the state in the d
 ilute phase and the condensate state\, due primarily to the multivalent in
 teractions between the constituents. In this talk\, I will first motivate 
 the conversion-limited scheme through a rugged energy landscape picture\, 
 and then elucidate its biophysical implications.References:[1] C. F. Lee\,
  J. Loken\, L. Jean\, and D. J. Vaux\, Elongation Dynamics of Amyloid Fibr
 ils: A Rugged Energy Landscape Picture\, Phys. Rev. E 80\, 041906 (2009).[
 2] A. W. Folkmann\, A. Putnam\, C. F. Lee\, and G. Seydoux\, Regulation of
  Biomolecular Condensates by Interfacial Protein Clusters\, Science 373\, 
 1218 (2021).[3] C. F. Lee\, Scaling Law and Universal Drop Size Distributi
 on of Coarsening in Conversion-Limited Phase Separation\, Phys. Rev. Res. 
 3\, 043081 (2021).
LOCATION:Seminar Room 1\, Newton Institute
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