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SUMMARY:Phase separation of +TIP-networks regulates microtubule dynamics -
  Charlotte Aumeier (University of Geneva)
DTSTART:20231012T080000Z
DTEND:20231012T084000Z
UID:TALK204901@talks.cam.ac.uk
DESCRIPTION:Regulation of microtubule dynamics is essential for diverse ce
 llular functions\, and proteins that bind to dynamic microtubule ends can 
 regulate network dynamics. Here we show that two conserved microtubule end
 -binding proteins\, CLIP-170 and EB3\, undergo phase separation and form d
 ense liquid-networks. When CLIP-170 and EB3 act together the multivalency 
 of the network increases\, which synergistically increases the amount of p
 rotein in the dense phase. In vitro and in cells\, these liquid networks c
 an concentrate tubulin. In vitro\, in the presence of microtubules\, phase
  separation of EB3/CLIP-170 can enrich tubulin all along the microtubule. 
 In this condition\, microtubule growth speed increases up to two-fold and 
 the frequency of depolymerization events are strongly reduced compared to 
 conditions in which there is no phase separation. Our data show that phase
  separation of EB3/CLIP-170 adds a novel layer of regulation to the contro
 l of microtubule growth dynamics.
LOCATION:Seminar Room 1\, Newton Institute
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