BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Unravelling Hidden Abilities Encoded in the Structure of DNA - Ale xei Kornyshev (Imperial College London) DTSTART:20231011T092000Z DTEND:20231011T100000Z UID:TALK204931@talks.cam.ac.uk DESCRIPTION:DNA molecule continues to surprise us with new abilities encod ed in its structure. I will overview some of the latest findings of the th eory and experiments related with the structural effects on DNA-DNA intera ctions is solutions\, with a focus on (i) DNA condensation and DNA mesopha ses\, and (ii) the ability of homologous genes to recognize each other fro m a distance prior homologous recombination. The latter will be the main p oint of the talk\, as it refers to one of the great mysteries of molecular genetics: how two homologous genes find each other in the genomic haystac k. I will emphasize new experiments performed at Imperial College and Harv ard University\, separately or together\, which bring new light on this fa scinating ability. The talk will summarize activities of a large team of p eople\, including groups at NIH (S. Leikin)\, Imperial (J. Baldwin\, J. Se ddon\, D.J. Lee\, and AAK)\; Harvard (M. Prentiss\, C. Danilowicz)\, Unive rsity of Minnesota (A. Wynveen) and few others.\nLiterature\n\nA. A. Korny shev\, D. J. Lee\, S. Leikin\, A. Wynveen\, Structure and interactions of biological helices\, Reviews of Modern Physics 79\, 943-996 (2007)\nA. A. Kornyshev\, Physics of DNA: unravelling hidden abilities encoded in the st ructure of 'the most important molecule&rsquo\;\, PCCP 39\, 12352-12378 (2 010) \;\nG. Baldwin\, N. Brooks\, R. Robson\, A. Goldar\, A. Wynveen\, S. Leikin\, J. Seddon\, A.A. Kornyshev Duplex DNA recognize sequence homo logy in protein free environment\, J. Phys. Chem. B 112\, 1060-1064 (2008) \nA. Falaschi\, Commentary: Similia similibus: pairing of homologous chrom osomes driven by the physicochemical properties of DNA\, HFSP Journal\, Oc tober 2\, 257&ndash\;261 (2008) http://www.ncbi.nlm.nih.gov/pmc/articles/P MC2639946/\nD.J.(O&rsquo\;) Lee\, C. Danilowicz\, C. Rochester\, A.A. Korn yshev\, M. Prentiss\, Evidence of protein-free homology recognition in mag netic bead force-extension experiments\, Proc. Roy.Soc. A 472\, #20160186 (2016) 10.1098/rspa.2016.0186\nD.J(O&rsquo\;) Lee\, A. Wynveen\, A.A. Korn yshev\, Theory of phase segregation in DNA assemblies containing two diffe rent base-pair sequence types\, New J. Phys. 19 # 015014 (2017) 10.1088/13 67-2630/aa5482\nD. J. Lee\, A. Wynveen\, T. Albrecht\, A.A. Kornyshev\, Wh ich way up? Recognition of homologous DNA segments in parallel and antipar allel alignment\, J.Chem.Phys. 142 \; #045101 \;(2015) https://doi .org/10.1063/1.4905291\nA.A. Kornyshev\, D.J. Lee\, A. Wynveen\, S. Leikin \, Signatures of DNA flexibility\, interactions and sequence-related struc tural variations in classical X-ray diffraction patterns\, Nucleic Acids R esearch 39\, 7289-7299 (2011)https://doi.org/10.1093/nar/gkr260\n\n\nR. Co rtini\, A. A. Kornyshev\, D. J. Lee\, S. Leikin\, Electrostatic braiding a nd homologous pairing of DNA double helices\n\nBiophys. J. 101\, 875-84 (2 011) https://doi.org/10.1016/j.bpj.2011.06.058 LOCATION:Seminar Room 1\, Newton Institute END:VEVENT END:VCALENDAR