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SUMMARY:Emergent oscillations during cellular directional decision-making 
 on junctions - Nir Gov (Weizmann Institute of Science)
DTSTART:20230921T100000Z
DTEND:20230921T110000Z
UID:TALK205504@talks.cam.ac.uk
DESCRIPTION:Motile cells inside living tissues often encounter junctions\,
  where their path branches into severalalternative directions of migration
 . We present a theoretical model of cellular polarization for cellsmigrati
 ng along one-dimensional lines\, arriving at a symmetric Y-junction and ex
 tending protrusionsalong the different paths that emanate from the junctio
 n. The model predicts the spontaneousemergence of deterministic oscillatio
 ns between competing protrusions\, whereby the cellular polarizationand gr
 owth alternates between the competing protrusions. The oscillations are mo
 dified bycellular noise\, but remain as a dominant feature which affects t
 he time it takes the cell to migrateacross the junction. These predicted o
 scillations in the cellular polarization during the directionaldecision ma
 king process at the junction are found experimentally for two different ce
 ll types\, noncancerousendothelial and cancerous glioma cells\, migrating 
 on patterned network of thin adhesivelanes with junctions.
LOCATION:Seminar Room 2\, Newton Institute
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