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SUMMARY:LMB Seminar: Feedback control of mitosis in the context of the kin
 etochore - Andrea Musacchio\, Director\, Department of Mechanistic Cell Bi
 ology\, Max-Planck-Institute of Molecular Physiology
DTSTART:20240923T100000Z
DTEND:20240923T110000Z
UID:TALK206374@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Kinetochores provide chromosomes with points of attachment to 
 spindle microtubules during cell division\, and are therefore essential fo
 r genome inheritance and the propagation of life. In addition to binding m
 icrotubules\, kinetochores control mitotic surveillance mechanisms that pr
 omote chromosome bi-orientation (the error correction mechanism) and preve
 nt premature mitotic exit in presence of incomplete or incorrect microtubu
 le attachments (spindle assembly checkpoint\, SAC). Elimination of the NDC
 80 complex\, the main microtubule receptor of kinetochores\, causes a SAC 
 deficiency\, identifying this complex as a crucial regulatory focus for ch
 eckpoint function. In recent years\, there has been considerable progress 
 in understanding how the SAC effector\, known as the mitotic checkpoint co
 mplex (MCC)\, assembles from its individual components to inhibit its targ
 et\, the anaphase promoting complex/cyclosome (APC/C). Conversely\, how mi
 crotubule attachment to kinetochores regulates the SAC remains incompletel
 y understood. From a molecular perspective\, answering this question impli
 es investigating the mechanisms that promote targeting of the SAC proteins
  to unattached kinetochores\, and suppress it upon microtubule binding and
  biorientation. In our recent work\, we have combined biochemical reconsti
 tutions\, structural biology/modelling\, and cell biology to gain insights
  into this fundamental biological question.  
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96608781341?pwd=MG5QMXVmOStX
 cFVtalBqUlBYc0tEdz09
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