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SUMMARY:Bigger Picture Talks - Can You Hear the Shape of a Crystal?  - Pro
 fessor Tim Korter\, Syracuse University
DTSTART:20231018T123000Z
DTEND:20231018T133000Z
UID:TALK207433@talks.cam.ac.uk
CONTACT:115369
DESCRIPTION:Please join us at the Department of Chemical Engineering and B
 iotechnology to hear Professor Tim Korter\, Syracuse University present hi
 s talk: Can You Hear the Shape of a Crystal? Terahertz Vibrational Spectro
 scopy of Challenging Pharmaceutical Crystals\n\nSolubility is a property o
 f great interest in the pharmaceutical industry where solid-state drug for
 mulations must maintain proper oral availability to be effective. The crys
 tal structures of pharmaceuticals are the key to understanding and enginee
 ring enhanced solubilities. However\, numerous drug molecules have unknown
  solid-state structures and new approaches are needed to address this. In 
 this work\, terahertz vibrational spectroscopy is used to measure the uniq
 ue low-frequency vibrations of molecular crystals. Material-specific terah
 ertz spectral signatures arise from the packing arrangements of the crysta
 l components. The terahertz data are then used in partnership with quantum
  mechanical crystal structure prediction methods to achieve complete three
 -dimensional structural information about these challenging pharmaceutical
  solids. An overview of the approach will be described using molecular exa
 mples ranging from simple maleic acid to the more complex glibenclamide th
 at highlight terahertz spectroscopy as an orthogonal means for solving pha
 rmaceutical crystal structures.
LOCATION:Lecture Theatre 1\, Department of Chemical Engineering  and Biote
 chnology\, New Museums Site
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