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SUMMARY:Computational Neuroscience Journal Club - Samuel Eckmann
DTSTART:20231031T140000Z
DTEND:20231031T150000Z
UID:TALK207907@talks.cam.ac.uk
CONTACT:Puria Radmard
DESCRIPTION:Please join us for our fortnightly Computational Neuroscience 
 journal club on Tuesday 31st October at 2pm UK time in the CBL seminar roo
 m\, or online on zoom.\n\nThe title is ‘Behavioural timescale synaptic p
 lasticity (BTSP)’\, presented by Samuel Eckmann.\n\nZoom information: ht
 tps://eng-cam.zoom.us/j/84204498431?pwd=Um1oU284b1YxWThObGw4ZU9XZitWdz09 M
 eeting ID: 842 0449 8431 Passcode: 684140\n\nSummary:\n\nSynaptic plastici
 ty is thought to be the physical correlate of learning. However\, despite 
 decades of research\, under what conditions synapses change their strength
 s and how this change relates to behavior remains controversial. In partic
 ular\, the millisecond timescale required for spike-timing-dependent plast
 icity (STDP) seems at odds with the learning of\, e.g.\, associations on a
  timescale of seconds to minutes. In contrast\, a recently introduced expe
 rimental paradigm induces ‘behavioral timescale synaptic plasticity’ (
 BTSP)\; strengthening synapses between neurons that fire seconds apart.\nI
  will first give an introduction to STDP\, highlighting some of the biolog
 ical complexities that challenge its usefulness as a general theory of syn
 aptic plasticity [1\, 2]. Finally\, I will present the BTSP paradigm [3]\,
  including recent findings of BTSP in hippocampus area CA3 [4].\n\n[1] Lis
 man\, J.\, & Spruston\, N. (2010). Questions about STDP as a general model
  of synaptic plasticity. Frontiers in synaptic neuroscience\, 2\, 140.\n[2
 ] O’Donnell\, C. (2023). Nonlinear slow-timescale mechanisms in synaptic
  plasticity. Current opinion in neurobiology\, 82\, 102778.\n[3] Bittner\,
  K. C.\, Milstein\, A. D.\, Grienberger\, C.\, Romani\, S.\, & Magee\, J. 
 C. (2017). Behavioral time scale synaptic plasticity underlies CA1 place f
 ields. Science\, 357(6355)\, 1033-1036.\n[4] Li\, Y.\, Briguglio\, J.\, Ro
 mani\, S.\, & Magee\, J. C. (2023). Mechanisms of memory storage and retri
 eval in hippocampal area CA3. bioRxiv\, 2023.
LOCATION:CBL Seminar Room\, Engineering Department\, 4th floor Baker build
 ing
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