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SUMMARY: Role of PRG-1 (plasticity related gene-1) in glutamatergic transm
 ission - Dietmar Schmitz\, Charité\, Berlin
DTSTART:20091118T161500Z
DTEND:20091118T180000Z
UID:TALK21124@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Plasticity related gene-1 (PRG-1) is a brain-specific membrane
  protein related to lipid phosphate phosphatases\, which acts in the hippo
 campus specifically at the excitatory synapse terminating on glutamatergic
  neurons. Deletion of prg-1 in mice leads to epileptic seizures and augmen
 tation of EPSCs\, but not IPSCs. In utero electroporation of PRG-1 into de
 ficient animals revealed that PRG-1 modulates excitation at the synaptic j
 unction. Mutation of the extracellular domain of PRG-1 crucial for its int
 eraction with lysophosphatidic acid (LPA) abolished the ability to prevent
  hyperexcitability. As LPA application in vitro induced hyperexcitability 
 in wild-type but not in LPA2 receptor-deficient animals\, and uptake of ph
 ospholipids is reduced in PRG-1-deficient neurons\, we assessed PRG-1/LPA2
  receptor-deficient animals\, and found that the pathophysiology observed 
 in the PRG-1-deficient mice was fully reverted. Thus\, we propose PRG-1 as
  an important player in the modulatory control of hippocampal excitability
  dependent on presynaptic LPA2 receptor signaling.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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