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SUMMARY:Antibodies by design: from drug development to brain drug delivery
  - Prof Peter M. Tessier\, University of Michigan
DTSTART:20240408T130000Z
DTEND:20240408T140000Z
UID:TALK212176@talks.cam.ac.uk
CONTACT:Echo Wu Williamson
DESCRIPTION:The biotech industry has seen an explosion in the development 
 of therapeutic antibodies in the last two decades\, and today most of the 
 best-selling drugs are monoclonal antibodies. The advantages of antibodies
  as therapeutics – namely their high affinity\, specificity\, potency\, 
 stability\, manufacturability\, and low toxicity – are compelling. Never
 theless\, there are many fundamental challenges associated with co-optimiz
 ing their key properties due to strong inherent tradeoffs\, such as affini
 ty/specificity\, affinity/stability\, and species cross-reactivity tradeof
 fs\, which greatly impede their development. I will discuss our progress i
 n addressing these challenges in a rational and predictive manner using ma
 chine learning\, including several examples of multi-objective optimizatio
 n ranging from antibody drug development to efficient and long-lived brain
  delivery of IgGs using bispecific antibodies.   
LOCATION:Department of Chemistry\, Cambridge\, Wolfson Lecture Theatre
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