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SUMMARY:Digital chimeras of the human atria to enable in silico trials at 
 scale - Axel Loewe (Karlsruhe Institute of Technology (KIT))
DTSTART:20240604T090000Z
DTEND:20240604T092000Z
UID:TALK214522@talks.cam.ac.uk
DESCRIPTION:Co-authors: Claudia Nagel (KIT)\, Luca Azzolin (KIT)\, Giorgio
  Luongo (KIT)\, Patricia Mart&iacute\;nez D&iacute\;az (KIT)\nComputer mod
 eling and simulation of cardiac function can be used in multiple ways to c
 ontribute to overcoming clinical challenges: i) as a basic research tool t
 o understand fundamental disease mechanisms\, ii) by identifying the optim
 al therapy for an individual patient using a digital twin\, iii) by genera
 ting large virtual cohorts of virtual chimeras for in silico trials identi
 fying the optimal therapy for specific patient subgroups or to enable mach
 ine learning on these scalable datasets. This talk focuses on the third ap
 proach. After introducing the basic methodology for introducing relevant v
 ariations of both anatomy and function\, we will give examples of how thes
 e methods have been used to contribute to risk stratification and decision
  support in the field of atrial arrhythmias.
LOCATION:Seminar Room 1\, Newton Institute
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