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SUMMARY:LMB Seminar: Mechanosensing in cancer invasion and metastasis - La
 ura M Machesky\, Sir William Dunn Professor of Biochemistry\, University o
 f Cambridge
DTSTART:20240617T100000Z
DTEND:20240617T110000Z
UID:TALK216970@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Pancreatic cancer is highly metastatic\, with a 5-year surviva
 l rate of less than 10%. Tumours are hallmarked by accumulation of highly 
 fibrotic extracellular matrix\, which correlates with poor prognosis and s
 pread to organs such as liver\, lung and peritoneal cavity. Our aim is to 
 understand the molecular connections between force sensing and aggressiven
 ess of tumour cells. We recently discovered a connection between mechanose
 nsing\, invasive migration and metabolic supply/demand in pancreatic cance
 r cells. I will discuss our model for how cells align their cytoskeletal p
 olarity with their metabolic machinery to meet the high demands of the can
 cer microenvironment. If we can better model and understand this alignment
 \, we can hope to find new ways to target the aggressiveness and spread of
  pancreatic cancer.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99537530757?pwd=UVk1YjIyeFY4
 QzNjNkhwa0xwbERoQT09
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