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SUMMARY:Human T cell immunity against tumour antigens - Dr Stephen Man\, U
 niversity of Cardiff
DTSTART:20100210T123000Z
DTEND:20100210T133000Z
UID:TALK21902@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:My group studies human T cells and their potential role in the
 rapy of pre-malignant and malignant diseases. Our main focus has been on h
 uman papillomaviruses (HPV) that are associated with the development of ce
 rvical cancer. We developed techniques to study HPV specific T cells respo
 nses for a series of phase I/II trials with a candidate therapeutic vaccin
 e (TA-HPV). We demonstrated that systemic T cell responses against HPV wer
 e relatively weak\, both in vaccinated and non-vaccinated patients. Nevert
 heless we could isolate and grow T cell clones from rare populations\, tha
 t could kill cancer cells in vitro. This suggests a therapeutic potential 
 for HPV specific T cells but new approaches will be required to induce lar
 ge numbers of efficacious T cells. We are currently defining new T cell ta
 rgets based on proteins that are abnormally expressed in cancer. These tar
 gets may be applicable to a broad range of human cancers\, particularly th
 ose caused by oncogenic viruses.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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