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SUMMARY:Biosynthesis Of Anti-Inflammatory Triterpene Fatty Acid Esters In 
 Calendula Officinalis - Connor Tansley (Patron Lab Group\, DPS)
DTSTART:20241107T121500Z
DTEND:20241107T134500Z
UID:TALK219952@talks.cam.ac.uk
CONTACT:115405
DESCRIPTION:*Abstract* \nPlants have been used in traditional medicine for
  thousands of years. In some cases\, therapeutic properties have been attr
 ibuted to specific metabolites\, enabling their use as drugs in modern med
 icine. However\, in many cases\, the exact molecule(s) responsible for the
  bioactivity of many plant extracts remains unknown. Further\, access to p
 lant natural products is often complicated by low abundance\, occurrence i
 n complex mixtures\, or by structural complexity\, which limit the feasibi
 lity of chemical synthesis. We are investigating the reported anti-inflamm
 atory floral extracts of Calendula officinalis (pot marigold)\, which have
  been used in medicine and skin care for centuries. In recent decades\, th
 is bioactivity has been associated with triterpene fatty acid esters (TFAE
 s). To identify the exact molecules responsible and elucidate the genetic 
 basis of their production\, we have combined multiomics with heterologous 
 expression Nicotiana benthamiana and anti-inflammatory bioassays in human 
 cell lines. Alongside this\, we are using metabolic engineering and genome
  editing to improve N. benthamiana as a sustainable production chassis for
  medium-scale production of triterpenes to enhance the evaluation of compo
 unds for medicine and agriculture.   \n\n*Please note the seminars are for
  University Of Cambridge members ONLY.*
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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