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SUMMARY:Myelin plasticity is required for opioid reward - Dr. Belgin Yalç
 ın (Michelle Monje group\, Stanford University)
DTSTART:20240903T130000Z
DTEND:20240903T140000Z
UID:TALK220120@talks.cam.ac.uk
CONTACT:Cahir O'Kane
DESCRIPTION:Summary\n\nAll drugs of abuse\, including opioids such as morp
 hine\, target the midbrain dopaminergic reward system and induce changes i
 n synaptic transmission and neural circuit function laying the foundations
  for developing addictive behaviors. While a significant role for microgli
 a and astrocytes in these neural circuit adaptations is becoming increasin
 gly apparent\, oligodendroglial lineage cells\, a glial cell type that is 
 particularly well positioned with its functions and interactions to contri
 bute to addiction\, remained unknown. This talk will focus on the previous
 ly unappreciated role of myelin plasticity in drug-evoked neural circuit a
 daptations which critically contribute to the behavioural reinforcing effe
 cts of opioids.\n\n \n\n \n\nThe Speaker\n\nBelgin Yalcin is an Instructor
  at Stanford University. Her work focuses on activity-regulated myelin pla
 sticity and its modulation of neural circuit function in health and diseas
 e. During her postdoctoral work at Stanford University working with Dr Mic
 helle Monje\, she investigatedneuron-oligodendroglia interactions and how 
 this communication regulates myelination and brain function. Dr Yalcin rec
 eived her PhD from the University of Cambridge in 2016. During her PhD wit
 h Dr Cahir O’Kane\, she demonstrated that health and function of long mo
 tor neuron axons depend on the continuous and elaborate organization of en
 doplasmic reticulum tubules\, disruptions of which may lead to axonal dege
 neration.
LOCATION:Part II Classroom\, Department of Genetics
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