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SUMMARY:Lessons for human TB and its treatment from the tiny transparent z
 ebrafish larva - Prof Lalita Ramakrishnan
DTSTART:20241022T170000Z
DTEND:20241022T183000Z
UID:TALK221122@talks.cam.ac.uk
CONTACT:Zhang Xianghao Jeffrey
DESCRIPTION:Lalita Ramakrishnan is a Professor of Immunology and Infectiou
 s Diseases at the University of Cambridge\, a Group Leader at the MRC Labo
 ratory of Molecular Biology\, and a Clinical Consultant in Infectious Dise
 ases at Cambridge University Hospital. She began researching tuberculosis 
 (TB) three decades ago\, motivated by the gravity of the disease—TB rema
 ins humanity’s most significant infectious disease—and the fascinating
  biology underlying it. She pioneered the use of transparent and genetical
 ly tractable zebrafish larvae to study TB. This model organism has provide
 d important insights into how TB bacteria cause disease and become toleran
 t to antibiotics. Her work is now translating into clinical studies and tr
 ials for human TB.\n\nLalita will share how she began working with zebrafi
 sh\, along with stories of how this model has helped identify why certain 
 people are more susceptible to TB and how TB bacteria exploit genetic vuln
 erabilities. Understanding these pathways has not only led to the developm
 ent of new drugs for TB but has also revealed new aspects of fundamental b
 iology. Lalita’s work has been recognized with many awards and honours. 
 She is a Fellow of the Royal Society and a member of the US National Acade
 my of Sciences. She is the recipient of the 2024 Robert Koch Award.
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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