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SUMMARY:Structure-function studies of essential mitochondrial complexes of
  apicomplexan parasites - Professor Lilach Sheiner\, University of Glasgow
DTSTART:20250319T160000Z
DTEND:20250319T170000Z
UID:TALK225553@talks.cam.ac.uk
CONTACT:127138
DESCRIPTION:Mitochondrial ribosomes (mitoribosomes) are essential\, and th
 eir function of synthesising mitochondrial proteins is universal. The core
  of almost all mitoribosomes is formed from a small number of long and sel
 f-folding rRNA molecules. \nIn contrast\, the mitoribosome of the apicompl
 exan parasite _Toxoplasma gondii_ assembles from over 50 extremely short r
 RNA molecules. We used cryo-EM structural analysis in combination with gen
 etics and cell biology to discover the features that enable this unusual m
 itoribosome to perform its function. \nOur studies revealed novel ribosome
  features that mitigate this extreme fragmentation\, including a new role 
 for Poly-A tails and abundant repurposing of proteins with other functiona
 l domains. \nWe further provide evidence for mitoribosome adaptation to th
 e mitochondrial genome irregularities found in _T. gondii_.\nAltogether\, 
 _Toxoplasma_'s unusual biology provided us with a magnifying glass to unde
 rstand new principles of mitoribosomes biology and function.   \n
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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