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SUMMARY:César Milstein Lecture: Mechanisms driving the rapid evolution of
  genomes - David Pellman - Dana-Faber Cancer Institute\, Harvard Universit
 y
DTSTART:20250424T090000Z
DTEND:20250424T100000Z
UID:TALK225721@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Genome evolution has long been viewed as a gradual process\, w
 ith small-scale genetic alterations accruing over many generations. Howeve
 r\, it is now appreciated that saltatory mutational events\, driving rapid
  evolution\, can be layered onto gradual Darwinian evolution. These episod
 ic events are particularly common in cancer\, where they generate highly r
 earranged genomes. At least some of these processes cause human congenital
  disease\, can be passed through the germline\, and may contribute to orga
 nismal evolution. My group has contributed to this paradigm by identifying
  mechanisms and consequences of these catastrophic mutational events\, lin
 king them to common errors in cell division. My talk will focus on the mec
 hanism of chromothripsis\, a catastrophic mutational process that originat
 es from aberrations in the architecture of the nucleus. I will focus on th
 e processes that fragment chromosomes during chromothripsis.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m link https://mrc-lmb-cam-ac-uk.zoom.us/j/97042445746?pwd=rjwSiStXxjdk1Q2
 tPOdRnqr8aM3qwn.1
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