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SUMMARY:LMB Seminar - The structures and mechanisms that maintain ciliary 
 proteostasis - In person only - Alan Brown\, Harvard Medical School
DTSTART:20250915T100000Z
DTEND:20250915T110000Z
UID:TALK228145@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION: Cilia are cell-surface organelles essential for sensory perce
 ption\, intercellular signaling\, cell locomotion\, and fluid flow generat
 ion. Proper maintenance of the ciliary proteome\, including removal of dam
 aged or mislocalized proteins as well as achieving the correct stoichiomet
 ry of signaling components\, is fundamental for these processes. Imbalance
 s in this maintenance are associated with a range of human ciliopathies in
 cluding polycystic kidney disease\, retinal degeneration\, and development
 al disorders such as Bardet-Biedl and Joubert syndromes. The temporospatia
 l distribution of proteins within cilia is regulated by intraflagellar tra
 nsport (IFT)\, wherein molecular trains shuttle between the cell body and 
 cilium. I will describe our efforts to structurally characterize the compo
 nents of IFT trains using single-particle cryo-EM. I will also describe a 
 newly identified coincidence detection mechanism that allows ubiquitinated
  proteins to be recognized and removed from cilia.  These findings advance
  our understanding of ubiquitin-mediated protein transport and ciliary pro
 teostasis\, and demonstrate how structural changes in IFT trains achieve c
 argo selectivity.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) 
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