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SUMMARY:Self or non-self? Detection of nucleic acids in the endolysosome -
  Prof. Dr. Veit Hornung\, Gene Center Munich
DTSTART:20250501T150000Z
DTEND:20250501T160000Z
UID:TALK228721@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:This Cambridge Immunology and Medicine Seminar will take place
  on Thursday 1 May 2025\, starting at 4:00pm\, in the Max Perutz Lecture T
 heatre\, MRC LMB\, Francis Crick Avenue.\n\nSpeaker: Professor Veit Hornun
 g\, Gene Center and Department of Biochemistry\, University of Munich\n\nT
 itle: 'Self or non-self? Detection of nucleic acids in the endolysosome'\n
 \nAbstract: A central function of our innate immune system is to detect mi
 crobial pathogens by the presence of their nucleic acid genomes or their t
 ranscriptional or replicative activity. In mammals\, a receptor-based syst
 em - represented by pattern recognition receptors (PRRs) - is primarily re
 sponsible for the detection of "non-self" nucleic acids. In recent years\,
  tremendous progress has been made in identifying the key sensing and sign
 aling components required for this complex task. The first group of PRRs i
 dentified as nucleic acid sensing receptors are the toll-like receptors (T
 LRs). TLRs are expressed as transmembrane receptors with their ligand bind
 ing domain facing either the extracellular space or the luminal compartmen
 t. A distinct evolutionary subset of TLRs is located in the endolysosomal 
 compartment\, which in the human system includes TLR7\, TLR8 and TLR9. Whi
 le TLR9 recognizes single-stranded DNA with unmethylated CG motifs\, which
  are indeed suppressed in the host genome\, TLR7 and TLR8 have evolved to 
 recognize RNA degradation products. Although there has been considerable r
 esearch on RNA-sensing TLRs\, our understanding of their capability to dif
 ferentiate between non-self and self-RNA remains limited\, particularly co
 nsidering the prevalence of self-RNA in the endolysosomal compartment. In 
 this talk\, I will provide an update on our recent work on this topic and 
 present some novel insights into how TLR7 and TLR8 discriminate self from 
 non-self.\n\nHost: Felix Randow\, MRC-LMB\, Cambridge\n\nRefreshments will
  be available following the seminar.\n\nPLEASE NOTE THE CHANGE OF VENUE
LOCATION:Max Perutz Lecture Theatre\, MRC LMB\, Francis Crick Avenue\, Cam
 bridge CB2 0QH 
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