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SUMMARY:LMB Seminar - Transmission of Misfolded Proteins in Neurodegenerat
 ive Disorders: A Common Mechanism of Disease Progression - Virginia Man-Ye
 e Lee\, Center for Neurodegenerative Disease Research\, University of Penn
 sylvania
DTSTART:20250408T103000Z
DTEND:20250408T113000Z
UID:TALK228976@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The formation of misfolded pathological protein aggregates by 
 disease-specific proteins is a common feature of many neurodegenerative di
 seases and are believed to cause neuronal dysfunction directly or indirect
 ly. Recent studies have strongly implicated cell-to-cell transmission of m
 isfolded proteins through templated recruitment as a common mechanism for 
 the onset and progression of various neurodegenerative disorders. Emerging
  evidence also suggests the presence of conformationally diverse “strain
 s” for each type of disease protein\, which may be another shared featur
 e of pathological aggregates\, accounting for the tremendous heterogeneity
  within each category of diseases. In Alzheimer’s disease and other age-
 related tauopathies\, the normally soluble tau protein accumulates as inso
 luble neurofibrillary tangles (NFTs)\, whereas in Parkinson’s disease an
 d other related synucleinopathies\, the highly soluble α-synuclein protei
 n are converted to aggregated Lewy bodies (LBs) in neuron and glia and fin
 ally TDP-43 forms cytoplasmic inclusions in frontotemporal dementia (FTLD-
 TDP) and amyotrophic lateral sclerosis (ALS).  We have developed in vivo t
 ransmission models of tauopathies\, synucleinopathies and TDP-43 proteinop
 athies and have used them to test the “transmission” hypothesis and th
 e “strain” hypothesis in order to elucidate mechanisms of progressive 
 spread of NFTs\, LBs and TDP-43 aggregates as well as to explore the molec
 ular basis of strain heterogeneity. Finally\, these and other insights on 
 pathogenesis will facilitate the development of novel therapies to treat t
 hese late-life neurodegenerative diseases.  
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m link https://mrc-lmb-cam-ac-uk.zoom.us/j/99931963515?pwd=6FBGl1amJG2tfvl
 9ycgkErGpbebGw3.1
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