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SUMMARY:Heterogeneity in Ion Binding for Bacterial Antimicrobial Resistanc
 e: Exquisitely Designed or Just Good Enough for The Job in Hand? - David J
   Scott (University of Nottingham)
DTSTART:20250912T081500Z
DTEND:20250912T085500Z
UID:TALK233374@talks.cam.ac.uk
DESCRIPTION:The cell operates at many levels:&nbsp\;\n(A) the molecular wh
 ere components have defined interactions that can be measured and structur
 ally described&nbsp\;in vitro&nbsp\;with high accuracy and related directl
 y to the&nbsp\;in vivo&nbsp\;context.&nbsp\;\n(B) cellular\, where the arr
 angements of components in the cell are vital to how it functions and resp
 onds to challenges.&nbsp\;\n(C) population\, where interaction between ind
 ividual cells and how they express different levels of protein components 
 dictates a functional outcome\,&nbsp\;\n(D) spatial\, where the arrangemen
 t in three dimensions dictates how a particular population of cells respon
 ds to their environment.&nbsp\;\nObviously these levels are interconnected
 \, and it is a question of how these respond allows us to understand the e
 merging properties of a cellular system.&nbsp\;\nWe have been interested f
 or a number of years in how bacteria respond to the challenges of differen
 t metal ions in their environment. This is of keen interest not only in un
 derstanding the fundamental underpinning biology but also in applications 
 of metal ions as powerful antimicrobials.&nbsp\;\nUsing the example of the
  copper/silver resistance system from&nbsp\;E.coli&nbsp\;we will examine h
 ow bacteria cope with heterogeneous metal challenges and the future challe
 nges in understanding the &nbsp\;response across the levels of described a
 bove.&nbsp\;
LOCATION:External
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