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SUMMARY:Virus‐host interactomics identify pathogen restriction factors a
 nd highlight the importance of non-canonical regulatory processes for anti
 viral immunity - Prof Andreas Pichlmair\, TUM School of Medicine and Healt
 h\, Technical University of Munich / DZIF\, German Center for Infection Re
 search
DTSTART:20251120T163000Z
DTEND:20251120T173000Z
UID:TALK236467@talks.cam.ac.uk
CONTACT:Liat Churley
DESCRIPTION:This Cambridge Immunology Network Seminar will take place on *
 Thursday 20 November 2025*\, starting at *4:30pm*\, in the Ground Floor Le
 cture Theatre\, Jeffrey Cheah Biomedical Centre (JCBC)\n\n*Speaker*: Prof 
 Andreas Pichlmair\, German Center for Infection Research (DZIF)\, Munich\,
  Germany\n\n*Title*: “Virus‐host interactomics identify pathogen restr
 iction factors and highlight the importance of non-canonical regulatory pr
 ocesses for antiviral immunity”\n\n*Abstract*: Viral infections belong t
 o the major causes of worldwide morbidity and mortality. Disease progressi
 on and outcome depend on pathogen-specific molecular interactions\, pertur
 bations and reactions of the immune system. \n\nMulti-omics-based characte
 risation of virus-host interactions allows unprecedented insights into vir
 al perturbations and associated immune responses. Loss-of-function analyse
 s and intersections with genetic data from patients with increased vulnera
 bility to viral infections facilitate the identification of host factors r
 elevant to virus propagation. I will showcase this on the basis of varicel
 la zoster virus–host interactions\, which highlight viral engagement of 
 E3 ligase complexes to modulate the innate immune response and patient mut
 ations in proteins involved in cytoskeletal reorganisation for viral sprea
 d. I will also discuss recent findings on pox- and influenza viruses\, whi
 ch indicate that specific cellular processes\, particularly housekeeping f
 unctions\, are relevant for virus propagation and are mostly regulated in 
 a non-canonical manner at the post-translational level.\n\nKnowledge of vi
 rus-host interactions not only enables a better understanding of viral pro
 pagation and disease progression but also facilitates the identification o
 f potential intervention strategies\, which could inform future therapeuti
 c approaches. \n\n*Host*: Prof Michael Weeks\, CIMR\, Cambridge\n\nRefresh
 ments will be available following the seminar.\n
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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