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SUMMARY:Interferon: Tug of War between Host and Pathogen - Dr Charlotte Od
 endall\, Senior Lecturer\, Department of Infectious Diseases\, King's Coll
 ege London
DTSTART:20260507T150000Z
DTEND:20260507T160000Z
UID:TALK237073@talks.cam.ac.uk
CONTACT:Liat Churley
DESCRIPTION:This Cambridge Immunology Network Seminar will take place on *
 Thursday 7th May 2026*\, starting at *4:00pm*\, in the Ground Floor Lectur
 e Theatre\, Jeffrey Cheah Biomedical Centre (JCBC)\n\n*Speaker*: Dr Charlo
 tte Odendall\, Senior Lecturer\, Department of Infectious Diseases\, King'
 s College London\n\n*Title*: Interferon: Tug of War between Host and Patho
 gen\n\n*Abstract*: Charlotte Odendall received her undergraduate and postg
 raduate degrees from Imperial College London. She carried out her graduate
  work on Salmonella pathogenesis under the supervision of David Holden. Sh
 e then joined the lab of Jonathan Kagan at Harvard Medical School/Boston C
 hildren’s Hospital to study host innate immune processes\, in particular
  the regulation of type I and III interferons. Charlotte then started her 
 lab as a Research Fellow\, funded by the Wellcome Trust and Royal Society\
 , at King’s College London\, where she is now a Senior Lecturer. The Ode
 ndall lab investigates immune responses to enteric bacteria\, as well as h
 ow bacterial pathogens manipulate host processes to colonise the host.\nIn
 terferons are induced during enteric bacterial infection and shape host de
 fence at mucosal surfaces. While best known for their antiviral roles\, in
 terferon responses also play important and context-dependent functions dur
 ing intracellular bacterial infection.\nIn this talk\, I will discuss how 
 interferon signalling influences infection and immunity in cellular and an
 imal models. Our work identifies interferon-stimulated genes that restrict
  bacterial infection and examines how the bacterial pathogens Salmonella a
 nd Shigella target these host defence programmes. Together\, these finding
 s highlight the dynamic interplay between host and pathogen at epithelial 
 barriers.\n\n\n*Host*: Dr Virginia Pedicord\, CITIID\, Cambridge\n\nRefres
 hments will be available following the seminar.
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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