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SUMMARY:Regulation of Alternative Splicing by Histone Modifications - Rein
 i Luco\, National Cancer Institute\, National Institutes of Health\, Bethe
 sda
DTSTART:20100402T130000Z
DTEND:20100402T140000Z
UID:TALK24007@talks.cam.ac.uk
CONTACT:Katrien Van Look
DESCRIPTION:Alternative splicing of pre-mRNA is a prominent mechanism to g
 enerate protein diversity\, yet its regulation is poorly understood. We de
 monstrated a direct role for histone modifications in alternative splicing
 . We found distinctive histone modification signatures that correlate with
  the splicing outcome in a set of human genes\, and modulation of histone 
 modifications causes splice site switching. Histone marks affect splicing 
 outcome by influencing the recruitment of splicing regulators via a chroma
 tin-binding protein. These results outline an adaptor system for the readi
 ng of histone marks by the pre-mRNA splicing machinery.
LOCATION:Cancer Research UK Cambridge Research Institute\, Room 215
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