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SUMMARY:Fishing for targets: chemical proteomics strategies for anti-paras
 itic drug target deconvolution - Professor Susan Wyllie\, University of Du
 ndee
DTSTART:20251203T160000Z
DTEND:20251203T170000Z
UID:TALK241204@talks.cam.ac.uk
CONTACT:127141
DESCRIPTION:Understanding the target and mode of action of compounds ident
 ified through phenotypic screening can greatly facilitate the process of d
 rug discovery and development. Chemical proteomics can provide a powerful\
 , unbiased route to the identification of the molecular targets of phenoty
 pically active compounds. Unlike many of the other approaches used for dru
 g target identification\, chemical proteomics has the distinct advantage o
 f providing evidence of on-target engagement\, demonstrating physical inte
 ractions between compounds of interest and their molecular targets. The Wy
 llie lab employ a broad range of chemical proteomics strategies to identif
 y the molecular targets of compounds showing promise for the treatment of 
 malaria and several neglected tropical diseases\, including standard chemi
 cal pulldown\, _µ_-mapping and thermal proteome profiling. The pros and c
 ons of each method will be discussed and examples of their practical use f
 or target ID given.
LOCATION:Lecture Theater\, Department of Pathology\, Tennis Court Road
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