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SUMMARY:POSTPONED\, new date t.b.c. Degrading Proteins in the Brain: Can w
 e get there and how can we make it work? - Will Farnaby\, University of Du
 ndee Centre for Targeted Protein Degradation
DTSTART:20260130T113000Z
DTEND:20260130T123000Z
UID:TALK243214@talks.cam.ac.uk
CONTACT:50597
DESCRIPTION:The Farnaby Group\, based in the University of Dundee Centre f
 or Targeted Protein Degradation\, are using induced proximity chemistry to
 wards the discovery of new tools and probes for Central Nervous System (CN
 S) disease understanding and treatment. This is a therapeutic area that ha
 s high unmet need and societal burden and where traditional small molecule
  approaches have had very little recent success for patients. There is a n
 eed for improved chemical tools that can help with target validation and u
 nderstanding and that can probe cellular signalling in new ways. In this t
 alk I will describe development of a direct-to-biology synthesis and scree
 ning approach to identify a brain active bifunctional degrader as well as 
 learnings from using multi-Kinase probes as a basis for mechanism agnostic
  molecular glue discovery. 
LOCATION:Clifford Allbutt Building Lecture Theatre\, Cambridge Biomedical 
 Campus
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