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SUMMARY:Sequencing 1000s of Human Genomes - Abecasis\, G (University of Mi
 chigan)
DTSTART:20100714T103000Z
DTEND:20100714T110000Z
UID:TALK25495@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Identifying and characterizing the genetic variants that affec
 t human traits is one of the central objectives of human genetics. Ultimat
 ely\, this aim will be achieved by examining the relationship between inte
 resting traits and the whole genome sequences of many individuals. Whole g
 enome re-sequencing of thousands of individuals is not yet feasible\, but 
 advances in laboratory methods (for example\, to enable the genotyping of 
 thousands of individuals at hundreds of thousands of SNP sites) and in sta
 tistical methodology (for example\, to enable accurate correction for popu
 lation stratification and genotype imputation) have resulted in substantia
 l progress in our understanding of complex disease biology. \nHere\, we di
 scuss practical study designs for the first generation of whole genome seq
 uencing studies. These will enable the examination of 1\,000s of individua
 ls at >10 million of polymorphic sites. These studies will be enabled by c
 ontinuing advances in laboratory technology and statistical methods and sh
 ould further refine our understanding of complex disease genetics. I illus
 trate the possibilities both with simulation and with data from the 1000 G
 enomes Project and other ongoing projects.\n
LOCATION:Seminar Room 1\, Newton Institute
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