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SUMMARY:Population genomics of bacterial pathogens - Parkhill\, J (Wellcom
 e Trust Sanger Institute)
DTSTART:20100715T150000Z
DTEND:20100715T153000Z
UID:TALK25511@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Bacterial genomes are around 1\,000 times smaller than vertebr
 ate genomes\, which suggests that we should be able to use current sequenc
 ing technologies to produce 1\,000 times more bacterial genomes per run. A
 lthough this is not yet logistically feasible\, using indexing protocols\,
  deep coverage of 96 genomes per run is possible. This data can provide ph
 ylogenetic and epidemiological data at unprecedented levels of detail\, al
 lowing us to study bacterial populations at the genomic level. I will pres
 ent recent data from experiments sampling collections of several hundred b
 acteria at global and local levels\, within specific\, highly related bact
 erial clades. These data allow us to study transmission pathways between c
 ontinents and between patients\, but they also give insights into populati
 on parameters such as rates of mutation and recombination within these cla
 des. Full analysis of these data sets\, and many more like them\, will req
 uire novel high-throughput analysis tools.
LOCATION:Seminar Room 1\, Newton Institute
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