BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The neuroinflammatory hypothesis of delirium - Joaquim Cerejeira\,
  Institute for Ageing and Health\, University of Newcastle
DTSTART:20101119T110000Z
DTEND:20101119T123000Z
UID:TALK27821@talks.cam.ac.uk
CONTACT:Daniel Davis
DESCRIPTION:Delirium is a neuropsychiatric syndrome characterized by a sud
 den and global impairment in consciousness\, attention and cognition. It i
 s particularly frequent in elderly subjects with medical or surgical condi
 tions and is associated with short- and long-term adverse outcomes. The pa
 thophysiology of delirium remains poorly understood as it involves complex
  multi-factorial dynamic interactions between a diversity of risk factors.
  Several conditions associated with delirium are characterized by activati
 on of the inflammatory cascade with acute release of inflammatory mediator
 s into the bloodstream. There is compelling evidence that acute peripheral
  inflammatory stimulation induces activation of brain parenchymal cells\, 
 expression of proinflammatory cytokines and inflammatory mediators in the 
 central nervous system. These neuroinflammatory changes induce neuronal an
 d synaptic dysfunction and subsequent neurobehavioural and cognitive sympt
 oms. Furthermore\, ageing and neurodegenerative disorders exaggerate micro
 glial responses following stimulation by systemic immune stimuli such as p
 eripheral inflammation and/or infection. In this review we explore the neu
 roinflammatory hypothesis of delirium based on recent evidence derived fro
 m animal and human studies.\n\n\n*Of special interest to*\n* *Medicine for
  the Elderly*\n* *Neurology*\n* *Old Age Psychiatry*\n* *Liaison Psychiatr
 y*
LOCATION:Alice Fisher Theatre\, S Block\, Addenbrooke's Hospital
END:VEVENT
END:VCALENDAR