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SUMMARY:Cryomicroscopy of calicivirus entry - Dr David Bhella\, MRC Virolo
 gy Unit\, Glasgow
DTSTART:20110119T163000Z
DTEND:20110119T173000Z
UID:TALK28475@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:We have previously shown that Feline Calicivirus binds to it's
  cellular receptor JAM-1 on the outer face of the P-domain of the capsid p
 rotein VP1 and that upon doing so undergoes conformational changes. We hyp
 othesise that these changes to the capsid structure may be the first step 
 of the uncoating pathway. In my talk I will discuss the results of our eff
 orts to improve the resolution of this structure and some of the challenge
 s posed. I will also go on to discuss our aims of using tomographic recons
 truction methods to investigate virus entry and uncoating in CRFK cells.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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