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SUMMARY:Epigenetic variation across generations: mechanisms and consequenc
 es of DNA methylation in Arabidopsis - Prof. Vincent Colot\, Unité de Bio
 logie Moléculaire des Organismes Photosynthétiques\, ENS\, France
DTSTART:20110310T160000Z
DTEND:20110310T170000Z
UID:TALK29183@talks.cam.ac.uk
CONTACT:Helen Scott
DESCRIPTION:The heritable basis of complex traits has long been assumed to
  depend on the transmission of DNA sequence alleles from parents to offspr
 ing. This view is however challenged by the observation that changes in ch
 romatin states can affect gene expression and can be inherited through mul
 tiple sexual generations independently of any DNA sequence change . This s
 o-called epigenetic inheritance of chromatin states is best documented in 
 plants and often involves DNA cytosine methylation and small RNAs. Yet\, w
 e still know very little about what causes epigenetic variation or how sta
 ble and prevalent it is. Here I will illustrate how epigenetic recombinant
  inbred lines (epiRILs)\, in which variation in DNA sequence is minimal co
 mpared to that  in DNA methylation\, can be used to assess the stability a
 nd phenotypic impact of epigenetic variants genome-wide and in an unbiased
  manner. \n\nhttp://www.biologie.ens.fr/a2e/spip.php?article13 
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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