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SUMMARY:Quality control in the IgM factory: the many roles of ERp44 - Robe
 rto Sitia\, San Raffaele Hospital\, MILAN
DTSTART:20110302T103000Z
DTEND:20110302T113000Z
UID:TALK29311@talks.cam.ac.uk
CONTACT:benedetta bolognesi
DESCRIPTION:A large fraction of the proteome is synthesized and folded in 
 the endoplasmic reticulum (ER)\, a multifunctional compartment also playin
 g pivotal  roles in Ca2+ storage\, redox homeostasis and signalling. From 
 the ER\, secretory proteins begin their journey towards their final desti
 nations\, the  organelles of the exocytic and endocytic compartments\, the
  plasma membrane or the extracellular space. Fidelity of protein-based int
 racellular  communication is guaranteed by quality control (QC) mechanisms
  located at the ER – Golgi interface\, which restrict forward transport 
 to native  proteins. QC is used also to time or shape the secretome. Furth
 ermore\, plasma cells and other professional secretory cells face the prob
 lem of producing proteins in high quantities. Our recent work on IgM bioge
 nesis sheds light on how cells couple fidelity and efficiency of secretion
  and identifies ERp44 as a key integrator of protein transport\, and Ca2+/
 redox homeostasis in the early secretory pathway
LOCATION:Unilever Lecture Theatre\,  Department of Chemistry
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