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SUMMARY:The Chemical Biology of Large-Scale Transcriptome Analysis - Kevin
  Weeks\, University of North Carolina
DTSTART:20110406T103000Z
DTEND:20110406T121500Z
UID:TALK30067@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Our laboratory is blending new RNA chemistries\, largely direc
 ted at the ribose 2'-hydroxyl group\, with quantitative interpretation to 
 create new kinds of chemical microscopes for highly accurate RNA structure
  analysis. We apply these technologies to important\, and otherwise intrac
 table\, problems in biology. We have developed a working model for the arc
 hitecture of an entire HIV-1 genome. This secondary structure model repres
 ents\, in essence\, a diverse set of hypotheses for how RNA structure gove
 rns viral replication. Recent functional studies supporting many of these 
 structural hypotheses\, plus new work focused on understanding RNA tertiar
 y structure\, will be emphasized.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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