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SUMMARY:Self-assembled DNA-nanostructure tools for molecular biophysics - 
 William Shih\, Harvard Medical School
DTSTART:20110725T151500Z
DTEND:20110725T170000Z
UID:TALK31580@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Our group previously solved a key challenge for nanotechnology
 : programmable self-assembly of complex\, three-dimensional nanostructures
 . Our solution was to build custom three-dimensional structures that can b
 e conceived as stacks of nearly flat layers of DNA. I will discuss applica
 tions of this technology for molecular biophysics: (1) weak-alignment medi
 a for NMR structure determination of membrane proteins such as UCP2\, a 30
  kDa six-transmembrane helix mitochondrial proton transporter\; (2) scaffo
 lds for determining the number of SNARE complexes required for lipid-bilay
 er fusion\; (3) artificial actin filaments built as chimeras between prote
 in and DNA for dissecting the mechanism of movement by processive myosin b
 ipedal walkers.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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