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SUMMARY:PDBe - Bringing Structure to Biology - Gerard Kleywegt\, EMBL-EBI
DTSTART:20110714T151500Z
DTEND:20110714T170000Z
UID:TALK31582@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:This year\, the Protein Data Bank (PDB) celebrates its 40th an
 niversary. To date\, the PDB has essentially been a historic archive captu
 ring structures (and the underpinning experimental data) of biomacromolecu
 les published in the primary literature. As the use of structural data by 
 non-experts becomes commonplace\, the demands on the archive (by both thes
 e users and funding agencies) and the way it is made accessible will inevi
 tably change. It is therefore necessary to transform sites that serve the 
 archive into resources that are directly relevant for scientists who work 
 in biomedicine and related disciplines\, while simultaneously taking care 
 not to alienate the communities that produce the structures. EMBL-EBI's Pr
 otein Data Bank in Europe (PDBe\; pdbe.org)\, one of the founders of the W
 orldwide Protein Data Bank (wwPDB\; wwpdb.org)\, is committed to becoming 
 such a resource. PDBe focuses on five areas:\n\n  - Advanced services (e.g
 .\, SSM\, Pisa\, PDBeMotif)\n  - Ligands (e.g.\, PDBeChem\; in the future 
 to include analysis\, validation\, visualisation and annotation services)\
 n  - Integration with other databases and resources (e.g.\, the SIFTS proj
 ect carried out in collaboration with UniProt\, and various structure brow
 sers and widgets that build on SIFTS data)\n  - Validation (implementing n
 ew tools and resources for X-ray\, NMR and cryo-EM)\n  - Experimental data
  (e.g.\, the Electron Density Server\, which will be ported from Uppsala t
 o PDBe\, and Vivaldi\, a new tool to visualise experimental NMR data on 3D
  models)\n\nSome of our recent and current work in these areas\, as well a
 s plans for the future will be discussed.\n\nFurther reading:\n\n- The Pro
 tein Data Bank in Europe (PDBe): bringing structure to biology. Velankar S
 . and Kleywegt G.J. 2011\, Acta Crystallographica D67\, 324-330. (http://s
 cripts.iucr.org/cgi-bin/paper?S090744491004117X)\n- PDBe: Protein Data Ban
 k in Europe. Velankar S.\, et al.\, and Kleywegt G.J. 2011\, Nucleic Acids
  Research\, 39 (Database issue)\, D402-D410. (http://nar.oxfordjournals.or
 g/content/39/suppl_1/D402)\n- PDBe: Protein Data Bank in Europe. Velankar 
 S.\, et al.\, and Kleywegt G.J. 2010\, Nucleic Acids Research\, 38 (Databa
 se issue)\, D308-17. (http://nar.oxfordjournals.org/content/38/suppl_1/D30
 8) 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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