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SUMMARY:Design and Analysis of Multi-Arm\, Multi-Stage Clinical Studies - 
 Dr. Thomas Jaki\, Department of Mathematics and Statistics\, Lancaster Uni
 versity
DTSTART:20111206T143000Z
DTEND:20111206T153000Z
UID:TALK32513@talks.cam.ac.uk
CONTACT:Li Su
DESCRIPTION:\nWe consider the problem of multiple comparisons with control
  in a\nclinical trial with treatment selection at the interim(s). Our\napp
 roach is an extension of group sequential methodology that involves\n join
 t monitoring of the correlated\, sufficient test\nstatistics. We show  the
  heavy computation involved can be\ndramatically reduced when the number o
 f stages is small and the number\nof treatments is large.\nWhen designing 
 the trial\, sample size can be chosen to satisfy a power\nrequirement base
 d on the least favourable configuration of treatment\neffects. At each ana
 lysis\, simultaneous confidence intervals are\neasily found such that the 
 overall coverage is at the required level. 
LOCATION:Large  Seminar Room\, 1st Floor\, Institute of Public Health\, Un
 iversity Forvie Site\, Robinson Way\, Cambridge
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