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SUMMARY:Randomization\, Regularization and Covariate Balance in Response-A
 daptive Designs for Clinical Trials - Atkinson\, A (London School of Econo
 mics)
DTSTART:20110830T100000Z
DTEND:20110830T103000Z
UID:TALK32565@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Results on the sequential construction of optimum experimental
  designs yield a very general procedure for generating response-adaptive d
 esigns for the sequential allocation of treatments to patients in clinical
  trials. The designs provide balance across prognostic factors with a cont
 rollable amount of randomization and speciable skewing towards better tre
 atments. Results on the loss\, bias and power of such rules will be discus
 sed and the importance of regularization will be stressed in the avoidance
  of extreme allocations. The designs will be considered in the wider conte
 xt of decisions about treatment allocation to patients within the study an
 d to the population of future patients.\n
LOCATION:Seminar Room 1\, Newton Institute
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