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SUMMARY:Interplay of Ecological and Evolutionary Processes in Infectious D
 isease Dynamics: Antimicrobial Resistance and Immune Escape - Dr Roger Kou
 yos\, Princeton
DTSTART:20110915T150000Z
DTEND:20110915T160000Z
UID:TALK32940@talks.cam.ac.uk
CONTACT:Prof. Julia Gog
DESCRIPTION:Although evolutionary (population genetic) and ecological (pop
 ulation dynamical) processes are often considered separately\, many phenom
 ena in infectious disease dynamics can only be properly understood as an i
 nteraction of both types of processes. I will present four examples that i
 llustrate the interaction between evolution and the spread of infectious d
 iseases. The first two examples deal with antimicrobial resistance in HIV-
 1 and Staphylococcus aureus. For HIV-1\, I will assess the impact of imper
 fect adherence on the evolution of antiretroviral-resistance at a within-h
 ost level. For Staphylococcus Aureus\, I will discuss to what extent popul
 ation structure can explain the coexistence between different antibiotic-r
 esistant strains. In the second part\, I will focus on evolutionary immuno
 logy and immuno-epidemiology. One of the crucial general questions in this
  context is\, which factors determine the speed of immune escape (or antig
 enic drift). I will discuss this question on the basis of a model\, which 
 combines the within-host with the epidemiological perspective. Finally\, I
  will present for measles virus the interaction between virus clearance an
 d immune-suppression\, which provides a snapshot of the evolutionary arms 
 race between the host and the parasite. 
LOCATION:CMS\, MR15
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