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SUMMARY:Stochastic signal encoding strategies in cells - James Locke\, Dep
 artment of Biology\, California Institute of Technology
DTSTART:20111010T150000Z
DTEND:20111010T160000Z
UID:TALK33621@talks.cam.ac.uk
CONTACT:21905
DESCRIPTION:How do cells respond to environmental signals? Until recently\
 , this fundamental question in biology seemed solved. Gene regulation circ
 uits\, whose structures resemble electrical circuits (e.g. feedback loops)
 \, appeared to regulate behavior in a deterministic fashion. However\, gen
 e circuits exhibit significant fluctuations\, (‘noise’)\, in their com
 ponents. It now appears that this noise can be functional\, enabling alter
 native regulatory strategies. However\, it remains unclear how genetic cir
 cuits use noise to control cellular behaviors. We have used a combination 
 of time-lapse microscopy\, mathematical modeling\, and synthetic biology t
 echniques to understand how the regulator of general stress response in B.
  subtilis\, controls its targets using a noise-dependent pulse frequency m
 odulation system.\n\n
LOCATION:The Sainsbury Laboratory Theatre
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