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SUMMARY:Rho GTPase signalling in tumour invasion - Chris Marshall\, ICR
DTSTART:20120215T190000Z
DTEND:20120215T203000Z
UID:TALK35520@talks.cam.ac.uk
CONTACT:20329
DESCRIPTION:Tumour cell migration is an essential component of invasion an
 d metastasis. Rho-family GTPase signalling coordinates the dynamic cytoske
 letal changes that are required for cell migration. To delineate Rho-famil
 y GTPase signalling in cell migration we are carrying out a systematic ana
 lysis of Rho-family GTPases their regulators and signalling pathways. Usin
 g RNA interference to target all Rho-family GTPases\, guanine nucleotide e
 xchange factors (GEFs) and GTPase activating proteins (GAPs) we have descr
 ibed pathways controlling two distinct forms of movement in melanoma cells
 . Elongated\, mesenchymal-type movement is driven by Rac activation mediat
 ed by a pathway containing the adaptor protein NEDD9 and the exchange fact
 or DOCK3. In contrast rounded/amoeboid movement is driven by Rho and Cdc42
  signalling to actomyosin contractility and suppressed by Rac activation. 
 To investigate how Rho GTPase signalling is regulated we have studied upst
 ream signalling events regulating the activation of Rac and actomyosin con
 tractility. These studies reveal new insights into transmembrane signallin
 g to Rho GTPases and demonstrate a tight interplay between Rho and Rac sig
 nalling in determining modes of cell movement.
LOCATION:Pharmacology Lecture Theatre\, Department of Pharmacology\, Tenni
 s Court Road
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