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SUMMARY:Structural and Biochemical Mechanisms of Synchronous Synaptic Tran
 smission - James Rothman\, Yale University
DTSTART:20120221T113000Z
DTEND:20120221T180000Z
UID:TALK35556@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:SNAREs fuse cellular membranes\, including synaptic vesicles w
 ith pre-synaptic plasma membranes to enable synaptic transmission.  SNAREs
  fuse membranes automatically\, so a clamp is needed to prevent premature 
 transmitter release\, provided by the protein complexin.  Recent studies h
 ave established the structural and biochemical mechanism of clamping by co
 mplexin involving a co-operative array of partly zippered SNAREpins whose 
 disolution can explain the syncronicity of transmitter release when the ca
 lcium sensor\, synaptotagmin\, perturbs the array.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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