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SUMMARY:Parasitic worms\, IgE\, immunity and allergy - Dr David Dunne\, De
 partment of Pathology\, University of Cambridge
DTSTART:20120208T163000Z
DTEND:20120208T173000Z
UID:TALK35708@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Parasite worms\, such as schistosomes\, still cause many milli
 ons of chronic debilitating infections amongst the rural poor in the devel
 oping world. Mass drug administration is the only current means to control
  these ‘neglected diseases’\, but treated individuals\, particularly c
 hildren\, become rapidly re-infected.  By studying populations living schi
 stosomiasis endemic areas\, we do see the slow development of adult immuni
 ty\, which is associated with IgE responses against allergen-like worm ant
 igens.  IgE is a major response in just two circumstances\, exposure to me
 tazoan parasites\, including worms\, and in the allergic diseases that hav
 e become epidemic in the developed world. The natural history of schistoso
 miasis in disease endemic African regions is providing new insights into t
 he induction/regulation of IgE and its effector mechanisms\, and into why 
 only a small number of protein structural families act as environmental an
 d food allergen targets for IgE-mediated allergic reactions. Such multi-di
 sciplinary studies in disease endemic areas can contribute knowledge to he
 lp combat disease in both the developing and developed world.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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