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SUMMARY:Molecular mechanisms of complement activation and regulation - Pie
 t Gros\, Utrecht University
DTSTART:20120419T130000Z
DTEND:20120419T150000Z
UID:TALK37240@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The complement system is an integral part of the innate immune
  defense in mammals. Complement is formed by ~30 large multi-domain plasma
  proteins and cell-surface receptors. This system enables to host to recog
 nize\, lyse and clear invading microbes and altered host cells from blood 
 and interstitial fluids\, while protecting healthy host tissue. Through st
 ructural studies we have revealed the molecular mechanisms responsible for
  the central amplification steps\, the host protection by complement regul
 ators and the initial events in formation of the membrane-attack complex (
 MAC). I will discuss the structural mechanisms\, which involve large struc
 tural rearrangements due to an interplay of proteolysis and complex format
 ion.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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