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SUMMARY:Molecular imaging of cancer: understanding chemotherapy response a
 nd resistance. - Dr Sarah Bohndiek\, Stanford University
DTSTART:20120530T100000Z
DTEND:20120530T110000Z
UID:TALK38427@talks.cam.ac.uk
CONTACT:Leona Hope-Coles
DESCRIPTION:Molecular imaging allows us to visualise and quantify biologic
 al processes in intact living organisms\, from cells\, to mouse to man. In
  this talk\, I will describe how molecular imaging is impacting clinical m
 edicine\, focusing on the detection and understanding of response to novel
  cancer therapeutics. Oxidative stress\, an imbalance of free radicals and
  antioxidants\, plays a key role in the initiation and progression of canc
 er.\nAt present\, our capabilities to observe and quantify redox processes
  in live cells and tissues are inadequate\, hence our knowledge of the rol
 e of free radicals in normal cell signalling and how this is disrupted in 
 malignant cells is limited. \n\nMy research aims to overcome this limitati
 on by developing new\, clinically translatable\, molecular imaging tools t
 o study the role of redox balance in cancer\, specifically in the evolutio
 n of drug resistant disease. Recent developments in optical imaging techno
 logies have led to the emergence of new contrast mechanisms that can be ex
 ploited for redox imaging\, using new instruments and contrast agents. The
  ability to study redox processes noninvasively could provide unprecedente
 d insight into the importance of redox biology in cancer progression\, wit
 h clinical application in the areas of early cancer detection and cancer t
 herapy. These tools will eventually enable studies of early lesion formati
 on in cancer and other pathologies\, including neurodegenerative disease.\
 n
LOCATION:Small Lecture Theatre\, Cavendish Laboratory\, Department of Phys
 ics
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