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SUMMARY:'Circulating Tumour Cells: Biomarker Utility and Insights to Metas
 tasis' - Professor Caroline Dive\, Clinical and Experimental Pharmacology 
 Group\, Paterson Institute for Cancer Research\, Manchester
DTSTART:20120814T110000Z
DTEND:20120814T120000Z
UID:TALK38913@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:Tissue biopsies are clearly the gold standard with which to in
 terrogate a patient’s tumour biology and assess biomarkers useful for tr
 eatment decision making. However\, for longitudinal monitoring of disease 
 in certain cancer types (e.g. lung and pancreas and particularly in patien
 ts with multiple metastatic lesions)\, serial biopsies may not be readily 
 acquired and easily repeatable and a less invasive tumour sample is requir
 ed.  With lung cancer as the main example\, this seminar will explore the 
 technology platforms for CTC analysis\, the prognostic significance of CTC
  number\, and the potential in early clinical trial settings for CTC assay
 s of predictive biomarkers and for demonstrating proof of drug mechanism a
 nd concept. The possibility to examine tumour evolution from a drug sensit
 ive to drug resistant phenotypes via CTC analysis will be discussed given 
 the current paradigms of response followed by relapsed witnessed for sever
 al targeted therapeutics. The biology of CTCs with respect to epithelial t
 o mesenchyme transition together with the relevance and composition of cir
 culating tumour microemboli will be also be addressed. Finally\, the horiz
 on of profiling CTCs will be touched upon and the biological relevance of 
 CTCs regarding intra-tumour heterogeneity will be debated. \n
LOCATION:CRI Lecture Theatre
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