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SUMMARY:Plant Metabolomics- an update - Alisdair Fernie\, Max-Planck-Insti
 tute\, Golm
DTSTART:20130207T130000Z
DTEND:20130207T140000Z
UID:TALK39041@talks.cam.ac.uk
CONTACT:Jill Harrison
DESCRIPTION:Metabolomics approaches enable the parallel assessment of the 
 levels of a broad range of metabolites and have been documented to have gr
 eat value in both phenotyping and diagnostic analyses in plants. These too
 ls have recently been turned to evaluation of the natural variance apparen
 t in metabolite composition. Here\, I will describe progress made in the i
 dentification of the genetic determinants of plant chemical composition\, 
 focussing on the application of metabolomics strategies and their integrat
 ion with other high-throughput technologies. I will use two examples to il
 lustrate this. Firstly\, by use of the quanitative trait loci approach I w
 ill describe work we and others have done to delineate the genetic underyl
 ing metabolite compositions (and its relationship with yield) in tomato. I
 n the second part of my lecture I will describe more recent work in which 
 we utilized natural variance\, recombinant inbred lines and knockout mutan
 ts in combination with a broad range of metabolomics techniques to define 
 novel phenylpropanoid pathway in the model plant Arabidopsis. Perhaps more
  importantly we were able to functionally demonstrate that the products of
  these pathways conferred UV-B resistance a fact that gave strong hints as
  to the processes of natural selection working at the metabolite level. Th
 ese two examples\, hopefully\, illustrate that metabolomics represents an 
 important addition to the tools currently employed in genomics-assisted se
 lection for crop improvement. 
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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