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SUMMARY:Max Perutz Lecture 2012: Defective DNA strand break repair\, genom
 e instability and cancer - Steve West\, CRUK LRI - Clare Hall
DTSTART:20120913T151500Z
DTEND:20120913T170000Z
UID:TALK39331@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:All living organisms feature DNA repair pathways that safeguar
 d the integrity of the genome\, and mutations in proteins that mediate key
  events in DNA repair have been linked to genome instability and tumourige
 nesis. Homologous recombination provides an important DNA repair pathway t
 hat is needed for the restoration and restart of broken replication forks\
 , for the rejoining of chromosome breaks\, and for the processing of DNA c
 rosslinks. Mutations in genes that encode a variety of recombination prote
 ins are linked to breast cancers and to inheritable diseases such as Bloom
 s Syndrome (BS) and Fanconi Anemia (FA). In recent work\, we purified the 
 BLM protein (defective in BS)\, the BRCA2 (FANCD1) and PALB2 (FANCN) tumou
 r suppressors (mutated in some cases of FA)\, and the newly discovered FAN
 CP protein\, also known as SLX4\, and have initiated structure-function an
 alyses to elucidate their molecular functions. How these proteins process 
 DNA\, and how they are regulated and controlled to direct the outcome of r
 ecombinational repair is now revealing unexpected insights that extend our
  understanding of efficient DNA repair and tumour avoidance. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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